TB-500 is a synthetic peptide representing the active region of thymosin beta-4, a naturally occurring protein found in nearly all human and animal cells. It consists of 43 amino acids with a molecular weight of approximately 4921 g/mol. Since its identification, TB-500 has become one of the most frequently referenced peptides in tissue repair and regenerative research.
TB-500’s primary research interest lies in its ability to upregulate actin, a cell-building protein essential for cell migration and proliferation. By promoting actin polymerization, TB-500 facilitates the movement of cells toward sites of injury — a process critical to wound healing and tissue regeneration models.
Research has also identified TB-500’s interaction with inflammatory pathways. Studies suggest it may downregulate certain inflammatory cytokines while promoting anti-inflammatory responses, making it a compound of interest in both acute and chronic inflammation models.
Published literature has examined TB-500 across a broad range of research contexts. Soft tissue repair, cardiac tissue regeneration, corneal healing, and hair follicle growth have all been subjects of investigation. Its role in promoting angiogenesis — the formation of new blood vessels — has drawn particular attention in wound healing research.
Additional studies have explored TB-500 in musculoskeletal models, examining its potential effects on tendon flexibility, muscle fiber repair, and joint mobility. Its systemic distribution profile makes it suitable for research requiring whole-body tissue interaction.
TB-500 and BPC-157 are frequently discussed together in regenerative research, though they operate through distinct mechanisms. BPC-157 demonstrates notable gastric stability and has been primarily studied in gastrointestinal and tendon-to-bone healing models. TB-500’s research focus centers on cell migration and systemic tissue repair. Some research protocols combine both compounds to explore potential complementary effects.
TB-500 is supplied as lyophilized powder and should be stored at -20°C for long-term stability. Once reconstituted with bacteriostatic water, the solution should be refrigerated at 2–8°C and used within a reasonable timeframe. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
At White Label Research, every batch of TB-500 undergoes third-party HPLC and mass spectrometry analysis. Certificates of analysis are available on the product page. Our standard purity threshold is ≥99%.
