NAD+ (nicotinamide adenine dinucleotide) is one of the most essential molecules in cellular biology. Present in every living cell, NAD+ functions as a coenzyme involved in metabolic reactions, energy production, DNA repair, and cellular signaling.
NAD+ participates in hundreds of enzymatic reactions throughout the body. Its primary role is as an electron carrier in metabolic pathways including glycolysis, the citric acid cycle, and oxidative phosphorylation, which collectively drive ATP production and cellular energy metabolism.
Beyond energy production, NAD+ also serves as a substrate for several important enzyme families including sirtuins, PARPs, and CD38. These enzymes are involved in processes related to DNA repair, stress response, immune signaling, and cellular communication.
Molecular formula: C21H27N7O14P2
Molecular weight: 663.43 g/mol
Research has identified a significant decline in NAD+ levels with age across multiple tissue types. Published studies have examined how reduced NAD+ availability may correlate with impaired mitochondrial function, decreased cellular repair activity, and altered metabolic regulation.
Additional research in aging models has explored whether restoring NAD+ levels may influence mitochondrial performance, cellular resilience, and metabolic health. These findings have contributed to growing interest in NAD+ within longevity and healthy aging research.
NAD+ continues to be widely studied in research involving neurodegenerative disease models, metabolic syndrome, cardiovascular function, exercise physiology, and immune response. Its role at the intersection of energy metabolism, cellular repair, and signaling pathways has positioned it as one of the most actively researched molecules in modern metabolic science.
Researchers are also investigating the relationship between NAD+ availability and mitochondrial health, particularly in contexts involving cellular stress and age-related metabolic decline.
NAD+ is supplied as a lyophilized powder for research purposes. Store at -20°C prior to reconstitution. Once reconstituted with bacteriostatic water, refrigerate at 2–8°C and avoid repeated freeze-thaw cycles to maintain stability.
At White Label Research, NAD+ undergoes third-party HPLC and mass spectrometry testing to verify identity and purity. Certificates of analysis are available on the product page. Our standard threshold is ≥99% purity.
