KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH). Despite consisting of only three amino acids, KPV has become a growing area of interest in inflammatory and immunological research.
KPV originates from α-MSH, a 13-amino acid neuropeptide known for its anti-inflammatory and immune-regulating properties. Researchers identified that the terminal lysine-proline-valine sequence retained much of the biological activity associated with the parent hormone, leading to focused investigation of KPV as an independent peptide compound.
Molecular formula: C16H30N4O4
Molecular weight: 342.43 g/mol
Research on KPV has primarily focused on its interaction with inflammatory signaling pathways. Published studies have examined its ability to inhibit NF-κB activation, a major regulator of inflammatory gene expression involved in numerous immune responses.
KPV has also demonstrated potential immunomodulatory activity in various experimental models. Researchers continue to investigate its effects on cytokine signaling, inflammatory mediator production, and epithelial tissue response.
Published research has explored KPV in gastrointestinal inflammation models, particularly those involving inflammatory bowel disease and mucosal tissue stress. Experimental findings have suggested potential effects on inflammatory marker expression and intestinal barrier support.
Additional studies have investigated possible antimicrobial properties associated with KPV. Research has examined activity against select bacterial strains, contributing to interest in the peptide’s combined inflammatory and microbial response profile.
KPV continues to attract attention in gut health, autoimmune, and inflammation-related research models. Its small molecular size, relative stability, and targeted biological activity make it a practical compound for in-vitro and preclinical experimentation across multiple areas of study.
KPV is typically supplied as a lyophilized powder for research purposes. Store at -20°C prior to reconstitution. Once reconstituted with bacteriostatic water, refrigerate at 2–8°C and avoid repeated freeze-thaw cycles to preserve peptide stability.
At White Label Research, KPV undergoes third-party HPLC and mass spectrometry testing to verify identity and purity. Certificates of analysis are available on the product page. Our standard threshold is ≥99% purity.
